Nick's take:
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgFtsRaszuthfWJWXwBn0OZP-Cri1sQTx-sZYNxnf9Y9gSOPgQSm4Fk0P1JhkYvJzoQmzbYkIDl73IyuqInKX0r8a_9JNtriUP50ZngKUbtBUcQKEQBJ3PhhZiQqLTP9amLtCsZaE0vxu4/s200/49ers+logo.gif)
Prediction: 49ers 28, Bills 10
Buffalo had little time to recover from its second-half meltdown against New England last week as it head into San Francisco, where the 49ers have won their last seven regular season games. San Fran has been a force on defense, the topper coming last week in their shutout victory against the Jets. An ailing backfield and a turnover-crazed Fitzpatrick will have a hard time against the league's third-ranked defense, and it will be a statement game for the Buffalo defense against a stout rushing tandem.
Dan's take:
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgFtsRaszuthfWJWXwBn0OZP-Cri1sQTx-sZYNxnf9Y9gSOPgQSm4Fk0P1JhkYvJzoQmzbYkIDl73IyuqInKX0r8a_9JNtriUP50ZngKUbtBUcQKEQBJ3PhhZiQqLTP9amLtCsZaE0vxu4/s200/49ers+logo.gif)
Prediction: 49ers 21, Bills 10
Sean's take:
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmo0Z1w3m5C1-Li0AnYVjoSgwXxeBkqUFFwZbHysDlKQ27Rz3s_HkXWXRZhyFKChOcPNhfQqTza6-Nf4rDnUMv6dzNDspl5n_pAFiXgB7snlauGjKhDvLgZjkaVcg-CuOeTc2UYKbb12M/s200/49ers+logo.gif)
Prediction: 49ers 27, Bills 3
Sam's take:
The Buffalo offense has had no problem scoring, but when it comes to stopping other teams from doing so, they've been virtually non-existent. Expect Alex Smith to outshine a gunslinging Ryan Fitzpatrick here.
Prediction: 49ers 31, Bills 21