Prediction: Bills 21, Rams 20 (Nick's record: 29-9)
Dan's take:The Bills' rushing attack is hitting its peak, right as the Rams' rush defense has hit rock bottom. Buffalo has seen some fairly significant players on both sides of the ball go down this week, but its offense will be too potent to let it show. Look for a heavy dose of the dynamic tailback duo, along with another impressive pass rushing performance against a porous offensive line.
Prediction: Bills 24, Rams 14 (Dan's record: 23-15)
Sean's take:Buffalo is coming off it's most complete game in quite some time but faces a much stronger opponent in the Rams. If head coach Chan Gailey repeats his idea of giving Jackson and Spiller a combined 42 touches, the Bills will find just as much success against a more-talented St. Louis defense.
Prediction: Bills 24, Rams 16 (Sean's record: 29-9)