Dan's take:Mike Pettine’s revamped defense will show its colors in the Bills' home opener, but Tom Brady’s Week 1 winning streak continues at the Ralph. Look for Stevan Ridley and the New England running game to be dominant against a defensive line that struggled mightily last year. If Brady can get into a rhythm with his young receiving corps against Buffalo's banged-up secondary, it may not be close.
Prediction: Patriots 24, Bills 17
The Bills already have too many issues defensively to hold their ground against the Patriots. With Stephon Gilmore out and Jairus Byrd likely sitting, Brady and his new weapons have their way in Orchard Park. C.J. Spiller will be impressive, as usual, but New England turns a few Buffalo three-and-outs into touchdowns and has the game in hand by halftime.
Sean's take:The Bills certainly believe their arrow is trending upward, but a Week 1 matchup against AFC East juggernaut New England all but guarantees a loss in head coach Doug Marrone's debut. It's business as usual for the Patriots, who batter a weakened Bills secondary and stifle Spiller en route to a big opening-day victory.
Prediction: Patriots 45, Bills 13